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KMID : 0359819940230020149
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Journal of Korean Neurosurgical Society
1994 Volume.23 No. 2 p.149 ~ p.159
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The Role of ELISA in Prediction of the Prognosis after Treatment of Neurocysticercosis
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문병관
긴남규/김영수/고용/오성훈/오석전/김광명
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Abstract
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The diagnosis of neurocysticercosis is relatively easy with brain computed tomograrhy(CT) and/or magnetic resonance imaging(MRI) and ELISA test of serum and cerebrospinal fluid (CSF). The clinical manifestation of the disease are varied and
correlated
with the infection sites. The use of praziquantel and/or surgical excision are effective in treatment of the disease.
The effect of treatment has been evaluated with imaging studies and changes of clinical manifestation. The authors reviewed 97 neurocysticercosis patients to evaluate the prognostic predictability of serum and CSF ELISA titers after treatment. We
classified the patients into two groups. Rebound group was patients which showed higher ELISA titers after praziquantel medication than pretreatment. Nonrebound group was that ELISA titers after treatment were lower than those of pretreatment.
The
responses to treatment were evaluated with the changes on brain CT or MRI.
The initial ELISA titers were lower in rebound group than those of nonrebound group, but three months after treatment, rebound group showed higher titers. The changes of ELISA titers in rebound group were greater in CSF than those in serum. The
reduction of cyst on brain CT or MRI was more remarkable in rebound group than in nonrebound group and the prognosis of rebound group was better. Changes of ELISA titer was valuable in predicting the effect of treatment and prognosis.
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KEYWORD
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